Journal
JOURNAL OF DENTISTRY
Volume 105, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jdent.2020.103566
Keywords
Dentine hypersensitivity; Tooth erosion; Stannous fluoride; Dentifrices; Meta-analysis; Pain
Categories
Funding
- Procter and Gamble Company
Ask authors/readers for more resources
This study aimed to compare the efficacy of bioavailable gluconate-chelated stannous fluoride toothpaste with control toothpastes for treatment of dentine hypersensitivity and enamel erosion. The results demonstrated that SnF2 toothpastes provided significant benefits for both dentine hypersensitivity and enamel erosion compared to control toothpastes.
Objectives: To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF2) toothpaste with control toothpastes for treatment of dentine hypersensitivity (DH) and enamel erosion. Data and sources: A Procter & Gamble Oral Care archive of clinical studies was reviewed from 2000 to 2020. Eligible studies were Randomised Controlled Trials (RCTs) investigating bioavailable gluconate-chelated SnF2 toothpaste efficacy compared to controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <= 2 months (DH); or by erosive toothwear (profilometry) from in-situ samples, duration 10-15 days. Two authors independently assessed eligibility and resolved disagreements by discussion. A meta-analysis was undertaken and Risk of Bias (RoB) assessed using the Cochrane collaboration RoB tool for randomized parallel-group and cross-over trials. Results: Fourteen RCTs (1287 participants) assessed DH relief and Six RCTs (184 participants) enamel erosion protection. For DH SnF2 toothpastes provided a 57 % (evaporative air) and 142 % (tactile) benefit versus negative controls (sodium fluoride/monofluorophosphate, 8 studies; p < 0.001). Compared to positive controls (potassium nitrate or arginine, 6 studies), a 22 % advantage (p = 0.036) was seen for evaporative air. In erosion studies, SnF2 toothpastes provided an 83 % benefit versus control toothpastes (arginine or sodium fluoride; p < 0.001) with a change (95 %CI) in average surface profilometry level (mu m) of -2.02(-2.85, -1.20). Conclusions: The use of these bioavailable SnF2 toothpastes, as part of a daily oral hygiene regimen, will provide patients with enamel erosion protection, combined with alleviation of DH pain when present, improving quality of life.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available