Journal
JOURNAL OF CONTROLLED RELEASE
Volume 330, Issue -, Pages 101-110Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2020.12.017
Keywords
Prostate cancer; Prostate-specific membrane antigen; Active targeting; Exosome mimetics
Funding
- Rosetrees Trust studentship 2016-2019 [M542]
- Prostate Cancer UK [CDF12-002]
- Engineering and Physical Sciences Research Council (EPSRC) [EP/M008657/1]
- EPSRC [EP/M008657/1] Funding Source: UKRI
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The engineered anti-PSMA peptide-targeted EMs showed increased cellular internalization in PSMA positive PC cell lines and higher tumor targeting ability in vivo, indicating their potential as a promising drug delivery system for advanced prostate cancer.
The present work describes the engineering of anti-PSMA peptide-decorated exosome mimetics (EMs) targeting advanced prostate cancer (PC). The targeted EMs were produced from anti-PSMA peptide, WQPDTAHHWATL, expressing U937 monoblastic cells, followed by successive extrusion cycles. The engineered EMs were nanosized, produced at a high yield, and displayed the anti-PSMA peptide, exosomal markers and monocytes proteins on their surface. As anticipated, PSMA-EMs showed increased cellular internalization in PSMA positive PC cell lines (LNCaP and C4-2B), compared to unmodified EMs. Most importantly, higher tumour targeting was observed in solid C4-2B tumours, following intravenous administration, confirming their targeting ability in vivo. Overall, our study indicates that the engineered anti-PSMA peptide-targeted EMs can be a promising drug delivery system for advanced PC.
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