Journal
JOURNAL OF CONTROLLED RELEASE
Volume 330, Issue -, Pages 1220-1228Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2020.11.028
Keywords
Cell penetrating peptides; Co-delivery; Targeted drug delivery; Blood brain barrier
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Cell penetrating peptides (CPP) have the ability to efficiently internalize across biological membranes, making them effective for delivering chemotherapeutic agents when combined with tumor targeting peptides.
Biological barriers hamper the efficient delivery of drugs and genes to targeted sites. Cell penetrating peptides (CPP) have the ability to rapidly internalize across biological membranes. CPP have been effective for delivery of various chemotherapeutic agents used to combat cancer. CPP can enhance delivery of drugs to a targeted site when combined with tumor targeting peptides. CPP can be linked with various cargos like nanoparticles, micelles and liposomes to deliver drugs and genes to the cancer cell. Here, we focus on CPP mediated delivery of drugs to the tumor sites, delivery of genes (siRNA,pDNA) and co-delivery of drugs and genes to combat drug resistance.
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