Performance and Implementation Evaluation of the Abbott BinaxNOW Rapid Antigen Test in a High-Throughput Drive-Through Community Testing Site in Massachusetts

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Upper Respiratory Tract of Children and Adults With Early Acute Coronavirus Disease 2019 (COVID-19)

Stephanie Baggio et al.

Summary: The study found that there were no significant differences in SARS-CoV-2 RNA loads between children and adults in the early stages of COVID-19.

CLINICAL INFECTIOUS DISEASES (2021)

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Letter Immunology

Correlation Between 3790 Quantitative Polymerase Chain Reaction-Positives Samples and Positive Cell Cultures, Including 1941 Severe Acute Respiratory Syndrome Coronavirus 2 Isolates

Rita Jaafar et al.

CLINICAL INFECTIOUS DISEASES (2021)

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Letter Respiratory System

Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with self-collected nasal swab versus professional-collected nasopharyngeal swab

Andreas K. Lindner et al.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Microbiology

Correlation of SARS-CoV-2 Nucleocapsid Antigen and RNA Concentrations in Nasopharyngeal Samples from Children and Adults Using an Ultrasensitive and Quantitative Antigen Assay

Nira R. Pollock et al.

Summary: Diagnosis of COVID-19 by PCR is sensitive, but the utility of detecting samples with high C-T values remains controversial. A new ultrasensitive immunoassay for SARS-CoV-2 nucleocapsid showed high sensitivity in samples with C-T values of <35, providing insight into the performance of Ag RDTs for COVID-19 diagnosis.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Infectious Diseases

Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres

Eliseo Albert et al.

Summary: The Panbio (TM) COVID-19 Ag Rapid Test Device performed well as a POC test for early diagnosis of COVID-19 in primary healthcare centres, with a specificity and sensitivity of 100% and 79.6% respectively. The negative predictive value of RAD was 99% and 97.9% under estimated prevalence of 5% and 10% respectively.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Review Microbiology

Performance of Saliva, Oropharyngeal Swabs, and Nasal Swabs for SARS-CoV-2 Molecular Detection: a Systematic Review and Meta-analysis

Rose A. Lee et al.

Summary: Nasopharyngeal (NP) swabs are considered the best sample for diagnosing SARS-CoV-2, but saliva, oropharyngeal (OP), nasal (NS) swabs, and combinations of OP/NS are promising alternatives. While some alternative samples had lower detection rates, a combination of OP/NS showed comparable performance to NP swabs. The absence of RNA extraction (saliva) and use of a more sensitive nucleic acid amplification test (NS) significantly reduced the positive yield of alternative samples.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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