Journal
JOURNAL OF CHEMICAL EDUCATION
Volume 98, Issue 3, Pages 996-1000Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jchemed.0c01355
Keywords
Upper-Division Undergraduate; Laboratory Instruction; Organic Chemistry; Hands-On Learning/Manipulatives; Inquiry-Based/Discovery Learning; Problem Solving/Decision Making; Amines/Ammonium Compounds; Applications of Chemistry; Catalysis; Coordination Compounds; Drugs/Pharmaceuticals; Industrial Chemistry; Organometallics; Synthesis
Funding
- Salisbury University's Henson School of Science and Technology
- Henson School of Science and Technology
- National Science Foundation [MRI-1827905]
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This three-part laboratory experiment explores key aspects of the Buchwald-Hartwig amination cross-coupling reaction through guided-inquiry learning strategies, including high-throughput experimentation techniques, result evaluation, preparative-scale reaction setup, and full characterization of target molecules. This experiment serves as the final experiment in the fourth-year undergraduate chemistry curriculum, providing students with a capstone learning experience.
This three-part laboratory experiment investigates key aspects of the Buchwald-Hartwig amination cross-coupling reaction through guided-inquiry learning strategies. The first part of this experiment utilizes high-throughput experimentation techniques to reinforce, explore, and extend fundamental concepts that are represented in the classroom, including the use of air-free Schlenk techniques and heteronuclear NMR analysis. The second component challenges students to evaluate their results to design, set up, and perform a preparative-scale Buchwald-Hartwig amination. Finally, students purify and isolate their products using column chromatography allowing them to fully characterize their target molecules through a variety of analytical techniques. This experiment represents one of the final experiments performed in the fourth-year undergraduate chemistry curriculum and serves as a capstone learning experience for students.
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