Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 25, Issue 8, Pages 3667-3679Publisher
WILEY
DOI: 10.1111/jcmm.16380
Keywords
biomarker; circRNA; colorectal cancer; drug resistance; therapeutic target
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2019-04545]
- Canadian Institutes of Health Research [PJT 162448]
Ask authors/readers for more resources
CircRNA plays a crucial role in colorectal cancer, affecting tumor growth, metastasis, and apoptosis, as well as drug resistance and unique associations with tumor size, staging, and overall survival, making them potential diagnostic and prognostic biomarkers.
Circular RNA (circRNA) is a highly abundant type of single-stranded non-coding RNA. Novel research has discovered many roles of circRNA in colorectal cancer (CRC) including proliferation, metastasis and apoptosis. Furthermore, circRNAs also play a role in the development of drug resistance and have unique associations with tumour size, staging and overall survival in CRC that lend circRNAs the potential to serve as diagnostic and prognostic biomarkers. Among cancers worldwide, CRC ranks second in mortality and third in incidence. In order to have a better understanding of the influence of circRNA on CRC development and progression, this review summarizes the role of specific circRNAs in CRC and evaluates their potential value as therapeutic targets and biomarkers for CRC. We aim to provide insight in the development of therapy and clinical decision-making.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available