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JOURNAL OF CELL BIOLOGY
Volume 220, Issue 3, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202101027
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The study by Murillo-Pineda and colleagues demonstrates the successful induction of a new functional centromere in human cells using CRISPR-Cas9, with long-read DNA sequencing providing strong evidence that centromere establishment is truly an epigenetic event.
Murillo-Pineda and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202007210) use CRISPR-Cas9-based genetic engineering in human cells to induce a new functional centromere at a naive chromosomal site. Long-read DNA sequencing at the neocentromere provides firm evidence that centromere establishment is a truly epigenetic event.
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