The mid-term outcome of Fontan conversion compared with primary total cavopulmonary connection

Background: : The indication of Fontan conversion (FC) from atriopulmonary connection (APC) to total cavopulmonary connection (TCPC) is unclear. We sought to analyze the mid-term outcome of prophylactic and therapeutic Fontan conversion compared with that of primary TCPC. Methods: : Patients with a univentricular heart who underwent cardiac catheterization at > 18 years of age between July 2005 and July 2019 were included and divided into three groups: symptomatic APC patients who underwent therapeutic FC (t-FC, n = 13), asymptomatic APC patients after prophylactic FC (p-FC, n = 15), and patients who had primary TCPC procedure (pTCPC, n = 24). Results: : The mean last follow up was at the age of 32.0 +/- 7.8, 26.8 +/- 3.8, and 27.3 +/- 7 years ( p = 0.07) in t-FC, p-FC, and pTCPC, respectively. There was no late death. All of t-FC and 12 (80%) of p-FC cases underwent concomitant arrhythmic surgery. Consequently, five and four patients in t-FC and p-FC groups required pacemaker implantations mostly due to sinus node dysfunction. Thromboembolism was seen in 2 cases in both t-FC (15%) and p-FC (13%), and 1 case in pTCPC (4%) ( p = 0.50). The last cardiac catheter-ization was performed at the age of 29.5 +/- 8.5, 24.6 +/- 3.8, and 26.3 +/- 7.1 years ( p = 0.11) in t-FC, p-FC, and pTCPC patients, respectively. There was no significant difference in central venous pressure, aortic pressure, and cardiac index among the three groups. There was no late supraventricular tachyarrhythmic event seen in t-FC and p-FC, whereas two patients in pTCPC had newly developed atrial flutter. Conclusions: : FC is a safe and feasible procedure to bring APC patients back onto the same track of primary TCPC patients in terms of hemodynamics as well as arrhythmia. The antiarrhythmic procedure should be carefully chosen because sinus node dysfunction can frequently occur and FC itself would re-duce the risk of arrhythmia. (c) 2021 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Automated summary

The study analyzed the mid-term outcomes of Fontan conversion (FC) compared to primary total cavopulmonary connection (TCPC) in patients with univentricular heart. The results showed that FC is a safe and feasible procedure that can bring atriopulmonary connection (APC) patients back onto the same track of primary TCPC patients in terms of hemodynamics as well as arrhythmia.