Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 147, Issue 9, Pages 2741-2750Publisher
SPRINGER
DOI: 10.1007/s00432-021-03531-8
Keywords
Squamous cell carcinoma of head and neck; Biomarkers; Programmed death-ligand; Poliovirus receptor
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Funding
- National Research Foundation of Korea (NRF) - Korean Government (MSIT) [NRF-2017M3A9E9072669, 2017M3A9E8029717, NRF2019M3A9B6065231(sc), 2018R1A2A1A05076997, 2017R1A5A1014560]
- National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea [HA16C0015, HA16C0015020019]
- Korea Health Promotion Institute [HA16C0015020019] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2017M3A9E8029717] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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PVR overexpression is a poor prognostic factor in patients with HNSCC, while co-targeting PVR and PD-L1 may be a promising therapeutic option that needs further investigation.
Purpose We aimed to investigate the prognostic value of multiple immune cell markers including programmed death-ligand 1 (PD-L1) and poliovirus receptor (PVR) in head and neck squamous cell carcinoma (HNSCC) using archival tumor tissues Methods Patients diagnosed with HNSCC who have undergone surgical resection in 2005-2012 were included. Correlations between PVR and PD-L1 expression and patient characteristics were analyzed by analysis of variance. The Kaplan-Meier method and log-rank test were used to estimate survival. P values < 0.05 were considered statistically significant. Results In total, 375 primary tumor tissues were analyzed using immunohistochemistry. High PVR expression was associated with a poor prognosis in terms of overall survival (OS) and recurrence-free survival (RFS), and tumors with high PVR expression were associated with a short OS. PD-L1 tumor expression did not have a prognostic impact on survival. Univariate analysis revealed that OS and RFS were affected by age and p16 and PVR expression; multivariate analysis revealed that age and p16 and PVR expression were the most important determinants of RFS. Conclusion PVR overexpression is a poor prognostic factor in patients with HNSCC and co-targeting PVR and PD-L1 may be a promising therapeutic option that needs further investigation.
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