Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 24, Issue 1, Pages 52-58Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2021.1877674
Keywords
Mangrove endophytic fungi; Pestalotiopsis sp; polyketides; structure identification
Funding
- High-level Talents Programs of Hainan Province [2019RC006]
- Key Science and Technology Project of Hainan Province [ZDKJ202018]
- National Natural Science Foundation of China [81973229/81660584]
- Key Project of Education Department of Hainan Province [Hnky2019ZD-6]
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Mangrove endophytic fungi have been proven to be a rich source of bioactive secondary metabolites, with two new polyketides identified in this study. Structural determination was done through NMR spectroscopic analysis and HR-ESIMS. All isolates were evaluated for their antimicrobial, antioxidant, and cytotoxic activities.
Mangrove endophytic fungi were proved to be a prolific resources for bioactive secondary metabolites. Two new polyketides, pestalotiopin B (1) and pestalotiopyrone N (2) were obtained from the ethyl acetate extracts of the rice solid cultures of the mangrove endophytic fungus Pestalotiopsis sp. HQD-6. The structures of 1 and 2 were determined by detailed interpretation of NMR spectroscopic analysis and HR-ESIMS. All of the isolates were evaluated for their antimicrobial, antioxidant and cytotoxic activities.
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