Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 69, Issue 10, Pages 3069-3081Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c07723
Keywords
melanoidin; structure; high-fat diet; gut microbiota; circadian rhythm
Funding
- Tianjin One Belt and One Road Technological Innovation Project [18PTZWHZ00080]
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The study found that black garlic melanoidins can partially reverse the dysrhythmia of intestinal microorganisms induced by a high fat diet, increase the number of bacteria producing short-chain fatty acids, and reduce the oscillation of inflammation-related bacteria.
The purpose of this study is to explore the effects of different molecular weight black garlic melanoidins (MLDs) on high fat diet (HFD) induced dysrhythmia of intestinal microorganisms. The results showed that a HFD disturbed the periodic fluctuation of the gut microbiome and that oral gavage of low molecular weight melanoidin (LMM) or high molecular weight melanoidin (HMM) reversed these cyclical variations in part, which resulted in an increase in the number of bacteria producing short-chain fatty acids (SCFAs) and a decrease in the oscillation of inflammation-related bacteria within a specific time period over the course of 1 day. Moreover, structural analysis showed different structure characterizations of LMM and HMM, which are related to the differences in flora oscillation. Therefore, the data showed that LMM and HMM relieve the circadian rhythm disorder of intestinal microbiota induced by a HFD in mice, which supported the further study of MLDs as a new dietary assistant strategy to improve chronic diseases.
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