4.7 Article

Dysfunctional frontal activation of mismatch negativity in panic disorder: A magnetoencephalographic study

Journal

JOURNAL OF AFFECTIVE DISORDERS
Volume 280, Issue -, Pages 211-218

Publisher

ELSEVIER
DOI: 10.1016/j.jad.2020.11.013

Keywords

Mismatch negativity (MMN); Panic disorder (PD); Inferior frontal gyrus (IFG); Magnetoencephalography (MEG)

Funding

  1. Chang Gung Memorial Hospital [CMRPD1E0291, CMRPD1E0292, CMRPD1E0293, CMRPD1E0294]
  2. Chang Gung University [BMRPE25]
  3. Healthy Aging Research Center, Chang Gung University from Featured Areas Research Center Program [EMRPD1K0431]
  4. Ministry of Science and Technology, Taiwan [MOST-104-2314-B-182-001-MY2, MOST-105-2628-B-182-004-MY3, MOST-108-2628-B-182-002, MOST-109-2628-B-182-012]

Ask authors/readers for more resources

Our study identified dysfunctional pre-attentive change-detection ability in patients with panic disorder, particularly in the inferior frontal gyrus (IFG), as indicated by reduced MMNm amplitudes. Higher trait anxiety scores were associated with lower MMNm amplitudes in the right IFG among patients with panic disorder.
Background: Mismatch negativity (MMN) or its magnetic counterpart (MMNm) is a neurophysiological signal to reflect the automatic change-detection ability. However, MMN studies in patients with panic disorder (PD) showed contrasting results using electroencephalographic (EEG) recordings. The present study attempted to overcome the limitations of EEG methodology by means of a whole-head magnetoencephalography (MEG) combined with the depth-weighted minimum norm estimate method to conduct an in-depth investigation on the MMNm at the cortical level in patients with PD. Methods: We recruited 22 healthy controls (HC) and 20 patients with PD to perform auditory oddball paradigm during MEG recordings. The cortical MMNm amplitudes and latencies in the superior temporal gyrus, inferior parietal lobule, and inferior frontal gyrus (IFG) were compared between the HC and PD groups. The correlations between MMNm responses and clinical measurement were also examined. Results: Compared with the HC group, the PD group demonstrated significantly reduced MMNm amplitudes in the IFG. Furthermore, higher trait scores of the State-Trait Anxiety Inventory were associated with lower MMNm amplitudes of the right IFG among patients with PD. Limitations: Generalization of the current results to other settings or samples should be made cautiously due to the use of different medication regimens and presence of comorbidities in our patients. Conclusions: Our data suggest dysfunctional pre-attentive change-detection ability in patients with PD, particularly in the IFG.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available