Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 86, Issue 3, Pages 344-352Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0000000000002544
Keywords
T cell; monocyte; HIV; lung function; spirometry
Categories
Funding
- Atlanta CRS [U01-HL146241]
- Baltimore CRS [U01-HL146201]
- Bronx CRS [U01-HL146204]
- Brooklyn CRS [U01-HL146202]
- Data Analysis and Coordination Center [U01-HL146193]
- ChicagoCook County CRS [U01-HL146245]
- Chicago-Northwestern CRS [U01-HL146240]
- Connie Wofsy Women's HIV Study, Northern California CRS [U01-HL146242]
- Los Angeles CRS [U01-HL146333]
- Metropolitan Washington CRS [U01-HL146205]
- Miami CRS [U01-HL146203]
- Pittsburgh CRS [U01-HL146208]
- UAB-MS CRS [U01-HL146192]
- UNC CRS [U01-HL146194]
- National Heart, Lung, and Blood Institute (NHLBI)
- Eunice Kennedy Shriver National Institute Of Child Health and Human Development (NICHD)
- National Institute on Aging (NIA)
- National Institute Of Dental and Craniofacial Research (NIDCR)
- National Institute Of Allergy And Infectious Diseases (NIAID)
- National Institute Of Neurological Disorders And Stroke (NINDS)
- National Institute Of Mental Health (NIMH)
- National Institute On Drug Abuse (NIDA)
- National Institute Of Nursing Research (NINR)
- National Cancer Institute (NCI)
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institute on Minority Health and Health Disparities (NIMHD)
- UCSF CTSA [UL1-TR000004]
- Atlanta CFAR [P30-AI-050409]
- UNC CFAR [P30-AI-050410]
- UAB CFAR [P30-AI-027767]
- IRG Award from the Nancy E. Taylor Foundation for Chronic Diseases, Inc.
- [K24HL087713]
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The expression of CD11b(+) on classical monocytes is positively associated with the FEV1/FVC ratio in people living with HIV, especially in those with good CD4 T-cell recovery. This suggests that this specific monocyte subset may play a role in preserving pulmonary function in PLWH.
Background: Maladaptive immune responses contribute to the pathogenesis of many chronic lung diseases. Here, we tested hypotheses that CD4 and CD8 T-cell and monocyte phenotypes are associated with lung function in people living with HIV and those without HIV. Methods: Markers of T cell differentiation, activation, exhaustion and senescence, and markers of monocyte recruitment and migration were quantified in 142 HIV-positive and 73 HIV-negative participants of the Pittsburgh HIV Lung Cohort. All participants underwent lung function testing. Results: CD4 or CD8 T-cell phenotypes were not associated with measures of lung function in HIV-positive or HIV-negative participants after adjustment for multiple comparisons. In HIV-positive participants, however, the percentage of classical monocytes that were CD11b(+) had positive associations at the Bonferroni-adjusted significance threshold of P = 0.05/63 with prebronchodilator and postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio (beta = 0.36; P = 0.00003 and beta = 0.31; P = 0.0003, respectively). In stratified analyses of n = 87 participants with CD4 >= 500 cells/mu L, associations of percentage of classical monocytes that were CD11b(+) with prebronchodilator and postbronchodilator FEV1/FVC ratio were stronger (beta = 0.48 and beta = 0.41, for pre- and post-, respectively) than in the entire HIV-positive study population. Significant associations of monocyte phenotypes were not observed in HIV-negative participants after adjustment for multiple comparisons. Conclusions: CD11b(+) expression on classical monocytes is positively associated with FEV1/FVC ratio in people living with HIV including in those with CD4 T-cell recovery. Given the normal surveillance activity of monocytes, such association suggests this monocyte subset may play a role in preservation of pulmonary function in PLWH.
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