Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 594, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.120142
Keywords
In-vitro; Drug release; Biorelevant; PLGA; Agarose; Implants; Hydrogel
Categories
Funding
- Charles University Grant Agency, project GA UK [850617/2017]
- Funding Agency of Charles University [SVV 260 4]
- German Academic Exchange Service (DAAD)
Ask authors/readers for more resources
The study proposed a method of using a thin agarose hydrogel layer to simulate tissue environment for drug-release testing of implantable formulations, showing significantly different release profiles compared with traditional testing in release medium alone, due to the physical restriction to swelling and deformation provided by the gel layer.
Current in vitro drug-release testing of the sustained-release parenterals represents the in vivo situation insufficiently. In this work, a thin agarose hydrogel layer surrounding the tested dosage form was proposed to mimic the tissue. The method was applied on implantable formulations of different geometries (films, microspheres, and cylindrical implants); prepared from various polymers (several Resomer (R) grades or ethyl cellulose) and loaded with different model drugs: flurbiprofen, lidocaine or risperidone. The hydrogel layer did not possess any retarding effect on the released drug and acted as a physical restriction to swelling and/or plastic deformation of the tested dosage forms. This led to a different surface area available for drug-release compared with testing in release medium alone and correspondingly to significantly different release profiles of the majority of the formulations obtained between the two methods (e.g. t50% = 18 days in pure release medium vs. t50% = 26 days in gel-setup for risperidone loaded Resomer (R) 503 H films or t50% = 7 days vs. t50% = 19 days for risperidone loaded Resomer (R) 503 H microspheres). The limited space for swelling and the rigidity of the agarose gel might mimic the tight encapsulation of the dosage form in the tissue better than the conventional liquid medium.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available