Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 597, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120349
Keywords
Physiologically based pharmacokinetic (PBPK) model; P-glycoprotein (P-gp); Drug-drug interactions (DDI); GastroPlus (TM); Advanced compartmental absorption and transit (ACAT) model
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The study evaluates the impact of P-gp efflux on edoxaban absorption in gastrointestinal tracts quantitatively using a PBPK model. The constructed model successfully demonstrates the significant contribution of P-gp in edoxaban's disposition in gastrointestinal tracts.
The purpose of this study was to evaluate the impact of P-glycoprotein (P-gp) efflux on edoxaban absorption in gastrointestinal tracts quantitatively by a physiologically based pharmacokinetic (PBPK) model constructed with clinical and non-clinical observations (using GastroPlus (TM) software). An absorption process was described by the advanced compartmental absorption and transit model with the Pgp function. A human PBPK model was constructed by integrating the clinical and non-clinical observations. The constructed model was demonstrated to reproduce the data observed in the mass-balance study. Thus, elimination pathways can be quantitatively incorporated into the model. A constructed model successfully described the difference in slopes of plasma concentration (Cp)-time curve at around 8 - 24 hr post-dose between intravenous infusion and oral administration. Furthermore, the model without P-gp efflux activity can reproduce the Cp-time profile in the absence of P-gp activity observed from the clinical DDI study results. Since the difference of slopes between intravenous infusion and oral administration also disappeared by the absence of P-gp efflux activity, P-gp must be a key molecule to govern edoxaban's PK behavior. The constructed PBPK model will help us to understand the significant contribution of P-gp in edoxaban's disposition in gastrointestinal tracts quantitatively.
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