Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms22052468
Keywords
depression; entorhinal cortex; hippocampus; memory; pattern separation; mood; neural circuitry; neurogenesis
Funding
- National Research Foundation of Korea (NRF) [2019R1A2C1090146]
- National Research Foundation of Korea [2019R1A2C1090146] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Depression affects both neural circuitry and neurogenesis, with defects in hippocampal activity and volume associated with depression-related behaviors. However, the mechanisms by which defective neural circuitry induces neurogenesis defects in depression remain unclear.
Depression is characterized by the disruption of both neural circuitry and neurogenesis. Defects in hippocampal activity and volume, indicative of reduced neurogenesis, are associated with depression-related behaviors in both humans and animals. Neurogenesis in adulthood is considered an activity-dependent process; therefore, hippocampal neurogenesis defects in depression can be a result of defective neural circuitry activity. However, the mechanistic understanding of how defective neural circuitry can induce neurogenesis defects in depression remains unclear. This review highlights the current findings supporting the neural circuitry-regulated neurogenesis, especially focusing on hippocampal neurogenesis regulated by the entorhinal cortex, with regard to memory, pattern separation, and mood. Taken together, these findings may pave the way for future progress in neural circuitry-neurogenesis coupling studies of depression.
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