Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms22052491
Keywords
3D cell culture; biomaterials; drug screening; alternative model
Funding
- Bio&Medical Technology Development Program of the National Research Foundation - Korean government [NRF-2016M3A9B4919655, NRF-2019M3A9H1103331]
- Basic Science Research Program of the National Research Foundation - Korean government [NRF-2020R1A2C2100794]
- National Research Foundation of Korea [2019M3A9H1103331, 2016M3A9B4919655] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The evaluation of drug efficacy and toxicity is crucial for the development of new drugs, with 3D cell culture playing a significant role in simulating human tissue functions.
The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening.
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