Chemical Constituents of the Bulbs of Scilla peruviana and Their Pancreatic Lipase Inhibitory Activity

Scilla species are used as medicinal plants and contain lanosterol-type triterpene glycosides. The phytochemical investigation of the bulbs of Scilla peruviana led to the isolation of 17 compounds, including three new rearranged pentacyclic-lanosterol glycosides (1-3) and two new homoisoflavanone glycosides (12 and 13). The structures of the undescribed compounds were determined by extensive spectroscopic analyses, including two-dimensional (2D) NMR. Among the triterpene glycosides, 2, 3, and 6 showed significant pancreatic lipase inhibitory activity in a concentration-dependent manner in vitro. The oral administration of scillascilloside D-2 (6) reduced serum triglyceride levels in a dose-dependent manner in soybean oil-loaded mice.

Automated summary

Scilla species are used as medicinal plants containing lanosterol-type triterpene glycosides. Phytochemical investigation of Scilla peruviana bulbs led to the isolation of 17 compounds, including new rearranged pentacyclic-lanosterol glycosides and homoisoflavanone glycosides. Among them, some compounds showed significant pancreatic lipase inhibitory activity in vitro and one compound reduced serum triglyceride levels in mice in a dose-dependent manner.