CD200:CD200R Interactions and Their Importance in Immunoregulation

The molecule CD200, described many years ago as a naturally occurring immunomodulatory agent, capable of regulating inflammation and transplant rejection, has attracted additional interest over the past years with the realization that it may also serve as an important marker for progressive malignancy. A large body of evidence also supports the hypothesis that this molecule can contribute to immunoregulation of, among other diseases, infection, autoimmune disease and allergy. New data have also come to light to characterize the receptors for CD200 (CD200R) and their potential mechanism(s) of action at the biochemical level, as well as the description of a novel natural antagonist of CD200, lacking the NH2-terminal region of the full-length molecule. Significant controversies exist concerning the relative importance of CD200 as a ligand for all reported CD200Rs. Nevertheless, some progress has been made in the identification of the structural constraints determining the interaction between CD200 and CD200R, and this information has in turn proved of use in developing novel small molecule agonists/antagonists of the interaction. The review below highlights many of these newer findings, and attempts to place them in the broad context of our understanding of the role of CD200-CD200R interactions in a variety of human diseases.

Automated summary

The molecule CD200, originally described as an immunomodulatory agent, has garnered interest for its potential role as a marker for cancer progression, in addition to its known roles in inflammation and transplant rejection. Research has also uncovered new insights into the receptors for CD200 (CD200R) and the development of novel agonists/antagonists for this interaction. Ongoing controversies exist regarding the importance of CD200 as a ligand for CD200Rs, but progress has been made in understanding the structural constraints of CD200-CD200R interactions.