Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms22052440
Keywords
optic coherence tomography; multiple sclerosis; EAE; optic nerve; demyelinating diseases; remyelinating drugs
Funding
- Asociacion Espanola de Esclerosis Multipe-Confederacion Espanola de Personas con Discapacidad Fisica y Organica (AEDEM-COCEMFE)
- Ministerio de Ciencia, Innovacion y Universidades [SAF2015-72325-EXP, SAF2016-77575-R, RD16-0019]
Ask authors/readers for more resources
This study validates the use of optical coherence tomography (OCT) to assess remyelination in multiple sclerosis (MS) patients and confirms the therapeutic potential of the small molecule VP3.15 as a neuroprotective, anti-inflammatory, and potentially remyelinating drug for MS therapy. The results emphasize the relevance of OCT for monitoring the efficacy of remyelinating therapies in vivo and highlight VP3.15 as a potential disease modifying drug for MS therapy.
The need for remyelinating drugs is essential for healing disabling diseases such as multiple sclerosis (MS). One of the reasons for the lack of this class of therapies is the impossibility to monitor remyelination in vivo, which is of utmost importance to perform effective clinical trials. Here, we show how optical coherence tomography (OCT), a cheap and non-invasive technique commonly used in ophthalmology, may be used to assess remyelination in vivo in MS patients. Our pioneer approach validates OCT as a technique to study remyelination of the optic nerve and reflects what is occurring in non-accessible central nervous system (CNS) structures, like the spinal cord. In this study we used the orally bioavailable small molecule VP3.15, confirming its therapeutical potential as a neuroprotective, anti-inflammatory, and probably remyelinating drug for MS. Altogether, our results confirm the usefulness of OCT to monitor the efficacy of remyelinating therapies in vivo and underscore the relevance of VP3.15 as a potential disease modifying drug for MS therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available