Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms22041821
Keywords
cancer cells; EMT; plasticity; migration; actin cytoskeleton; E-cadherin; adherens junctions
Funding
- Russian Science Foundation [16-15-10288]
- Russian Foundation for Basic Research [18-54-16005]
- Russian Science Foundation [16-15-10288] Funding Source: Russian Science Foundation
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Cancer cells exhibit phenotypic plasticity through rearrangements of the cytoskeleton and adherens junctions, allowing them to survive and thrive in alien environments by achieving advantageous epithelial/mesenchymal phenotypes.
There is ample evidence that, instead of a binary switch, epithelial-mesenchymal transition (EMT) in cancer results in a flexible array of phenotypes, each one uniquely suited to a stage in the invasion-metastasis cascade. The phenotypic plasticity of epithelium-derived cancer cells gives them an edge in surviving and thriving in alien environments. This review describes in detail the actin cytoskeleton and E-cadherin-based adherens junction rearrangements that cancer cells need to implement in order to achieve the advantageous epithelial/mesenchymal phenotype and plasticity of migratory phenotypes that can arise from partial EMT.
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