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Fabrication and Applications of Microfluidic Devices: A Review

Journal

Publisher

MDPI
DOI: 10.3390/ijms22042011

Keywords

microfluidic devices; fabrication techniques; chip materials; biomedical applications; drug delivery; organ-on-a-chip

Funding

  1. Romanian National Authority for Scientific Research and Innovation, UEFISCDI [TE 103, PN-III-P1-1.1-TE-2019-1450]

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Microfluidics is an emerging field that combines principles from various disciplines to fabricate miniaturized chips with channels and chambers. These chips, made using diverse methods, can be utilized in nanoparticle preparation, cell analysis, and diagnosis, among other biomedical applications.
Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.

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