Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms22041844
Keywords
thymus; immune system; skin; 2; 3; 7; 8-tetrachlorodibenzo-p-dioxin (TCDD); aryl hydrocarbon receptor (AHR); therapeutic target
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Identifying historical trajectories is helpful in research to clarify important shifts in science. This review discusses the role of AHR in linking environmental pollution toxicity with healthy adaptive immune and skin responses, revealing opportunities for targeting AHR in treating various diseases.
Identifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even paradigmatic, shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor aryl hydrocarbon receptor (AHR) as a mediator of the toxicity of environmental pollution towards a link between the environment and a healthy adaptive response of the immune system and the skin is discussed. From this fascinating development, the opportunities for targeting the AHR in the therapy of many diseases become clear.
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