Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 148, Issue 11, Pages 2779-2788Publisher
WILEY
DOI: 10.1002/ijc.33475
Keywords
association study; long noncoding RNA; pancreatic cancer; single nucleotide polymorphism
Categories
Funding
- DKFZ
- Fondazione Arpa
- Ministry of Health of Czech Republic [NV 19-03-00097, NV 19-09-00088]
- Italian Ministry of Health [RC1803GA32]
- Fondazione Tizzi
- 5x1000 voluntary contribution
- Ministry of Health of the Czech Republic [NV19-08-00113]
- Charles University [UNCE/MED/006]
- Ministry of Health, Czech Republic [NV18/03/00199]
- BMBF [01GS08114, 01ZX1305C, 01KT1506]
- Heidelberger Stiftung Chirurgie
- Biomaterial Bank Heidelberg [01EY1101]
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A new PDAC risk locus was identified, with genetic variation disrupting the binding between lncRNA and miRNA possibly affecting the development of PDAC.
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 x 10(-9)). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.
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