Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 174, Issue -, Pages 502-511Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.01.203
Keywords
Tragacanth gum; Hydrogel; Anticancer drug delivery; Green synthesis; Silver nanocomposites; Antimicrobial activity
Funding
- Basic Science Research Program through NRF of South Korea - Ministry of Education [NRF-2 2019R1I1A3A01063627]
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This study investigated the synthesis and characterization of natural polymer-based stimuli-responsive hydrogels and their silver nanocomposites, demonstrating their potential applications for controlled release of anticancer drugs and inactivation of multidrug resistant bacteria.
This study investigated natural polymer-based stimuli-responsive hydrogels (TGIAVE) and their silver nanocomposites (TGIAVE-Ag). The hydrogels were composed of tragacanth gum, N-isopropyl acrylamide, and 2-(vinlyoxy) ethanol and were prepared via simple redox polymerization using N,N'-methylene-his-acrylamide as a crosslinker and potassium persulfate as an initiator. The TGIAVE-Ag were synthesized via a green method involving an aqueous extract of Terminalia bellirica seeds. Structural, thermal, crystallinity, morphology, and size characteristics of the TGIAVE and TGIAVE-Ag were investigated by FTIR, UV-Vis, XRD, DSC, SEM, EDS, DLS, and TEM. To understand the physicochemical interaction and diffusion characteristics of TGIAVEs, network parameters such as zero-order, first-order, Hixson-Crowell, Higuchi, and Korsmeyer-Peppas values were calculated by assessing swelling data. TGIAVE hydrogels at pH 12 and 7.4 and temperatures of 25 and 37 degrees C may be used for time-dependent controlled release of 5-fluorouracil, an anticancer drug, TGIAVE-Ag may be applied for the inactivation of multidrug resistant (MDR) bacteria. (C) 2021 Elsevier B.V. All rights reserved.
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