Bacterial exopolysaccharides: Chemical structures, gene clusters and genetic engineering

In recent decades, the composition, structure, biosynthesis, and function of bacterial extracellular polysaccharides (EPS) have been extensively studied. EPS are synthesized through different biosynthetic pathways. The genes responsible for EPS synthesis are usually clustered on the genome or large plasmids of bacteria. Generally, different EPS synthesis gene clusters direct the synthesis of EPS with different chemical structures and biological activities. A better understanding of the gene functions involved in EPS biosynthesis is critical for the production of EPS with special biological activities. Genetic engineering methods are usually used to study EPS synthesis related genes. This review organizes the available information on EPS, including their structures, synthesis of related genes, and highlights the research progress of modifying EPS gene clusters through gene-editing methods. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

In recent decades, there has been extensive research on the composition, structure, biosynthesis, and function of bacterial extracellular polysaccharides (EPS), highlighting the crucial role of EPS in biological activities.