Preparation of aerogel beads and microspheres based on chitosan and cellulose for drug delivery: A review

Spherical aerogels are not easily broken during use and are easier to transport and store which can be used as templates for drug delivery. This review summarizes the possible approaches for the preparation of aerogel beads and microspheres based on chitosan and cellulose, an overview to the methods of manufacturing droplets is presented, afterwards, the transition mechanisms from sol to a spherical gel are reviewed in detail followed by different drying processes to obtain spherical aerogels with porous structures. Additionally, a specific focus is given to aerogel beads and microspheres to be regarded as drug delivery carriers. Furthermore, a core/shell architecture of aerogel beads and microspheres for controlled drug release is described and subjected to inspire readers to create novel drug release system. Finally, the conclusions and outlooks of aerogel beads and micro-spheres for drug delivery are summarized. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

This review focuses on the preparation and application of spherical aerogels for drug delivery, with a specific emphasis on their potential as drug carriers. Various innovative approaches and future prospects are proposed to inspire readers in creating novel drug release systems.