Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 131, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2020.105908
Keywords
Src; Mechanosensing; Integrins; Cytoskeleton; p130Cas; YAP
Categories
Funding
- project Center for Tumour Ecology - Research of the Cancer Microenvironment Supporting Cancer Growth and Spread of the Ministry of Education, Youth, and Sports of the Czech Republic [CZ.02.1.01/0.0/0.0/16_019/0000785]
- Czech Science Foundation [18-15684J, 19-03932S]
Ask authors/readers for more resources
Cells have developed a unique set of molecular mechanisms to probe the mechanical properties of their surrounding environment and transform mechanical stimuli into versatile biochemical information. Src kinase plays a central role in the mechanotransduction network, working in cooperation with primary sensors and the cytoskeleton to execute cellular responses and adaptations to mechanical cues.
Cells have developed a unique set of molecular mechanisms that allows them to probe mechanical properties of the surrounding environment. These systems are based on deformable primary mechanosensors coupled to tension transmitting proteins and enzymes generating biochemical signals. This modular setup enables to transform a mechanical load into more versatile biochemical information. Src kinase appears to be one of the central components of the mechanotransduction network mediating force-induced signalling across multiple cellular contexts. In tight cooperation with primary sensors and the cytoskeleton, Src functions as an effector molecule necessary for transformation of mechanical stimuli into biochemical outputs executing cellular response and adaptation to mechanical cues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available