Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 91, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2020.107283
Keywords
Sirt1; Bax; Resveratrol; Tuberculosis; Macrophage; Apoptosis
Categories
Funding
- National Natural Science Foundation of China [81371776]
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Sirt1 regulates apoptosis signaling in Mycobacterium tuberculosis infection, and its activation may serve as a potential candidate for the prevention and treatment of tuberculosis.
Apoptotic pathways play an important role in Mycobacterium tuberculosis -infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in many mammalian cells. However, the apoptotic role of Sirt1 in the process of M. tuberculosis infection remains unclear. With the help of mouse macrophage samples, 129/Sv background mice, and PBMCs-derived macrophages from healthy controls and patients with tuberculosis, we have shown that M. tuberculosis infection reduced Sirt1 mRNA and protein expression, however, increased Bax mRNA and protein expression. Further, we found that resveratrol, a Sirt1 activator, inhibited M. tuberculosis -induced Bax expression. Thus, it seems that Sirt1 acts as a novel regulator of apoptosis signaling in M. tuberculosis infection via its effects on Bax. Sirt1 activation may therefore be a new candidate for the prevention and treatment of tuberculosis.
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