4.2 Article

Intravenous Mineralocorticoid Receptor Antagonist Use in Acutely Decompensated Heart Failure with Diuretic Resistance

Journal

INTERNATIONAL HEART JOURNAL
Volume 62, Issue 1, Pages 193-196

Publisher

INT HEART JOURNAL ASSOC
DOI: 10.1536/ihj.20-442

Keywords

Congestive heart failure; Furosemide; Dyspnea; Cardiac edema; Cardiovascular diseases; Potassium canrenoate

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Intravenous mineralocorticoid receptor antagonists (MRAs) have been successfully used as a rescue procedure in patients with acutely decompensated heart failure (ADHF) and diuretic resistance. Further trials evaluating the effects of this therapeutic strategy in ADHF could be promising.
Intravenous mineralocorticoid receptor antagonists (MRAs) have been used in some centers for decades to reduce the risk of hypokalemia and boost diuresis in acutely decompensated heart failure (ADHF). We report the well-tolerated use of intravenous MRAs as a rescue procedure in 3 patients admitted for ADHF with important diuretic resistance. Undertaking trials evaluating the effect of this therapeutic strategy in ADHF could represent a promising avenue.

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