The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis

Background To our knowledge, data on the effects of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis are limited. This study was conducted to determine the effects of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis. Methods The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 18-40 years old) with endometriosis. Participants were randomly allocated into two groups (30 participants each group) to receive either 50,000 IU vitamin D or placebo each 2 weeks for 12 weeks. Results Vitamin D supplementation significantly decreased pelvic pain (beta - 1.12; 95% CI, -2.1, -0.09; p=.03) and total-/HDL-cholesterol ratio (beta - 0.29; 95% CI, -0.57, -0.008; p=.04) compared with the placebo. Moreover, vitamin D intake led to a significant reduction in high-sensitivity C-reactive protein (hs-CRP) (beta - 0.64 mg/L; 95% CI, -0.97, -0.30; p<.001) and a significant increase in total antioxidant capacity (TAC) (beta 47.54 mmol/L; 95% CI, 19.98, 75.11; p=.001) compared with the placebo. Conclusions Overall, our study demonstrated that vitamin D intake in patients with endometriosis resulted in a significant improvement of pelvic pain, total-/HDL-cholesterol ratio, hs-CRP and TAC levels, but did not affect other clinical symptoms and metabolic profiles.

Automated summary

The study suggests that vitamin D supplementation in patients with endometriosis can significantly reduce pelvic pain, decrease total-/HDL-cholesterol ratio, lower hs-CRP levels, and increase TAC levels.