4.4 Article

Systemic contribution of inflammatory mediators to the severity of diabetic and uveitic macular edema

Journal

Publisher

SPRINGER
DOI: 10.1007/s00417-021-05149-5

Keywords

Diabetic macular edema; Uveitic macular edema; Cytokine; Interleukin-6; Interleukin-8; Macular volume

Categories

Funding

  1. Ministry of Science and Innovation of Spain, Instituto de Salud Carlos III [PI17/00316]
  2. Generalitat de Catalunya [2017 SGR 0701]

Ask authors/readers for more resources

This study found that serum IL-6 and IL-8 levels in peripheral blood are associated with the severity of diabetic macular edema (DME) and uveitic macular edema (UME) respectively. IL-8 appears to be independently correlated with central macular thickness and macular volume in UME cases. Such systemic implications could enhance personalized diagnostic and therapeutic approaches for DME and UME.
Purpose To assess whether serum cytokine and growth factor levels are associated with diabetic macular edema (DME) and uveitic macular edema (UME) objective severity. Methods Cross-sectional observational study of 81 patients (1 eye/patient) with DME (n=48) and UME (n=33). Macular edema (ME) was defined upon central macular thickness (CMT) >= 300 mu m on spectral domain optical coherence tomography (OCT). Serum samples were obtained from peripheral blood and IL-1 beta, IL-6, IL-8, IL-10, MCP-1, TNF-alpha, and VEGF levels were determined by Luminex analysis. Main outcome measure was the correlation between mediators' levels and CMT and macular volume (MV) on OCT for ME cases. Results In DME, IL-6 levels were found to significantly correlate with MV (r=0.324; p=0.028) whereas in UME, IL-8 was significantly associated with both CMT (r=0.401; p=0.021) and MV (r=0.391; p=0.024). IL-8 independently correlated with CMT (ss=177.2; p=0.033) and MV (ss=3.17; p=0.008) in UME multivariate model. Conclusion Peripheral blood IL-6 and IL-8 levels could play a role in the severity of DME and UME, respectively. IL-8 even seems to be independently associated with CMT and MV in UME cases. Such systemic implications could enforce DME and UME personalized diagnostic and therapeutic approaches.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available