4.6 Article

A haplotype of the ANGPTL3 gene is associated with CVD risk, diabetes mellitus, hypertension, obesity, metabolic syndrome, and dyslipidemia

Journal

GENE
Volume 782, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.gene.2021.145525

Keywords

CVD; Haplotype; ANGPTL3; Diabetes; Hypertension; Obesity; Metabolic syndrome; and dyslipidemia

Funding

  1. Birjand University of Medical Science
  2. Mashhad University of Medical Science, Iran

Ask authors/readers for more resources

This study aimed to investigate the association between three variants of the ANGPTL3 gene and cardiovascular disease risk factors, with findings indicating that the GTC and CTC haplotypes may help identify individuals with a genetic susceptibility to cardiometabolic disorders.
Subject: There have been a few studies on the association between the angiopoietin-like 3 (ANGPTL3) single nucleotide polymorphisms (SNPs) and the risk of cardiovascular disease (CVD). But there is no consensus about the association of ANGPTL3 haplotypes and cardiometabolic disorders. We aimed to determine the association of three variants of the ANGPTL3 gene and CVD risk factors, which included: diabetes mellitus, hypertension, obesity, metabolic syndrome, and dyslipidaemia in the MASHAD population cohort. Method: DNA extraction and genotyping were undertaken in1002 individuals who were recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort. The association between the rs1748195, rs11207997, and rs10789117 variants with CVD event following 6 years follow-up and individual CVD risk factors were assessed using multivariate analysis. Result: Individuals with a GTC haplotype had a reduced risk of CVD, dyslipidaemia, obesity, and DM. Moreover, we found that of all 8 haplotypes, the CTC was associated with a 1.5-fold higher risk of HTN. Carriers of an uncommon allele of the ANGPTL3 gene had a lower risk of obesity, HTN, MetS and DM (rs10789117), and in those with the rs1748195 variant there was a lower risk of obesity compared to the wild-type genotype. Conclusion: We found that the GTC and CTC haplotypes of the ANGPTL3 gene may help identify individuals with a genetic susceptibility to cardiometabolic disorders.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available