Tacrolimus Use and COVID-19 Infection in Patients After Solid Organ Transplantation

Article Gastroenterology & Hepatology

Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients

Jordi Colmenero et al.

Summary: This study revealed that liver transplant patients have a higher risk of contracting COVID-19, but their mortality rate is lower than the general population. Baseline immunosuppression containing mycophenolate was identified as an independent predictor of severe COVID-19, especially at higher doses.

JOURNAL OF HEPATOLOGY (2021)

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Article Surgery

Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients

David C. Gaston et al.

Summary: Research on SOT recipients suggests that the dynamics of SARS-CoV-2 virus in this population and that C-T values may not predict the severity of COVID-19 but may be more useful in guiding infection prevention measures.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Immunology

A Report of 85 Cases of COVID-19 and Abdominal Transplantation From a Single Center: What Are the Associated Factors With Death Among Organ Transplantation Patients

Seyed Ali Malekhosseini et al.

Summary: This study reports the epidemiology of COVID-19 among recipients of organ transplantation and evaluates factors associated with death. Among liver, kidney, kidney-pancreas, and liver-kidney recipients, a total of 85 patients were found to have acquired COVID-19, with common symptoms including fever, cough, myalgia, and fatigue. One-third of the patients had oxygen saturation below 90% on admission, and 20% of patients died, with higher mortality rates observed in pediatric patients and those with low albumin levels. Low albumin levels were found to be associated with a higher risk of death in transplant recipients with COVID-19.

TRANSPLANTATION (2021)

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Article Immunology

Biomarkers of Cytokine Release Syndrome Predict Disease Severity and Mortality From COVID-19 in Kidney Transplant Recipients

Ilies Benotmane et al.

Summary: This study analyzed clinical characteristics and prognosis of kidney transplant recipients with COVID-19, finding that early elevations of C-reactive protein and interleukin-6 were significantly associated with disease severity and mortality, highlighting the importance of regularly monitoring cytokine storm biomarkers to improve clinical outcomes.

TRANSPLANTATION (2021)

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Article Gastroenterology & Hepatology

Protective Role of Tacrolimus, Deleterious Role of Age and Comorbidities in Liver Transplant Recipients With Covid-19: Results From the ELITA/ELTR Multi-center European Study

Luca S. Belli et al.

Summary: Despite concerns, data from adult liver transplant recipients with COVID-19 infection in Europe shows that age over 70, diabetes, and chronic kidney disease are associated with increased risk of death, while the use of tacrolimus may improve survival rates in these patients.

GASTROENTEROLOGY (2021)

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Article Surgery