Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 164, Issue -, Pages 187-205Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2021.01.018
Keywords
ROS; Coenzyme Q; Mitochondria; Ageing; Complex I; Complex III; Redox signalling
Funding
- BBSRC [BB/R008167/2, BB/R008167/1] Funding Source: UKRI
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Mitochondria are essential for producing energy in cells, but they also generate Reactive Oxygen Species (ROS) which play a critical role in determining cell fate and maintaining cellular homeostasis. Accumulation of defective mitochondria during aging leads to high levels of ROS production, causing oxidative stress and disrupting redox signaling.
Mitochondria are the powerhouses of the cell. They produce a significant amount of the energy we need to grow, survive and reproduce. The same system that generates energy in the form of ATP also produces Reactive Oxygen Species (ROS). Mitochondrial Reactive Oxygen Species (mtROS) were considered for many years toxic byproducts of metabolism, responsible for ageing and many degenerative diseases. Today, we know that mtROS are essential redox messengers required to determine cell fate and maintain cellular homeostasis. Most mtROS are produced by respiratory complex I (CI) and complex III (CIII). How and when CI and CIII produce ROS is determined by the redox state of the Coenzyme Q (CoQ) pool and the proton motive force (pmf) generated during respiration. During ageing, there is an accumulation of defective mitochondria that generate high levels of mtROS. This causes oxidative stress and disrupts redox signalling. Here, we review how mtROS are generated in young and old mitochondria and how CI and CIII derived ROS control physiological and pathological processes. Finally, we discuss why damaged mitochondria amass during ageing as well as methods to preserve mitochondrial redox signalling with age.
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