Journal
FORENSIC SCIENCE INTERNATIONAL-GENETICS
Volume 53, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.fsigen.2021.102495
Keywords
Insertion/deletion; Forensic genetics; Native Americans; Admixed populations; South America; Population substructure
Categories
Funding
- Laboratorio de Genetica y Biologia Molecular, Bogota - Colombia
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq [306342/2019-7]
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro - FAPERJ [CNE-2018]
- Vicerrectoria de Investigacion y extension de la Universidad Industrial de Santander (VIE-UIS) [5694]
Ask authors/readers for more resources
The population of Colombia has genetic heterogeneity due to migrations from different continents and within the country. It is important to consider this population stratification in forensic analysis, especially for markers with marked intercontinental differentiation. The study found that a set of 38 indels could be useful in individual identification studies in Colombia, showing high levels of discrimination and exclusion power complementing with other markers.
The current population of Colombia has a genetic heterogeneity resulting from different migrations from other continents and within the country. In addition, there are small groups in their territory that have remained isolated and therefore have a different genetic pool in relation to that of the neighbouring urban populations. This population stratification must be considered in forensic analysis, being more complex for markers with marked intercontinental differentiation. In this study, population differentiation in Colombian admixed, native, and Afro-descendant populations was evaluated for a group of 38 indels described for forensic use. Allelic frequencies and parameters of forensic relevance were determined in each of the groups defined based on population differentiation analyses. In addition to the differences found between population groups, the results show that the set of 38 indels analysed could be useful in studies of individual identification in Colombia. The exclusion power presented by this set of markers suggests the need for joint use with other markers, being able to complement the STRs in paternity cases. High levels of both power of discrimination and exclusion were found when complementing the 38 HID-indels with a second multiplex, for a total of 83 indels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available