Journal
FOOD HYDROCOLLOIDS
Volume 112, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2020.106291
Keywords
Resveratrol; Pickering emulsion; Starch nanocrystal; Chitosan coating; Mucoadhesive; Bioaccessibility
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2016R1D1A1B03936106, NRF-2019R1A6A3A13090082, NRF-2020R1A6A3A03037247]
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By loading resveratrol in chitosan-coated emulsions, the retention time and bioavailability of resveratrol can be enhanced, prolonging its bioactivity and improving its adhesion on intestinal mucosa. Furthermore, the resveratrol-loaded chitosan-coated emulsions exhibit high stability, providing valuable insights for the development of an effective oral delivery system for resveratrol.
To enhance its gut health-promoting activity and bioaccessibility, resveratrol was loaded in emulsions stabilized by octenyl succinic anhydride-modified waxy maize starch nanocrystals and then coated with chitosan. Resveratrol loaded in > 0.1% chitosan-coated emulsions adhered more robustly onto porcine intestinal mucosa than did resveratrol powder (23-fold) and chitosan-uncoated emulsions (7-fold). Unlike chitosan-uncoated emulsions, chitosan-coated emulsions were stable during gastric digestion and slowly hydrolyzed in a small intestinal environment. After in vitro digestion, > 90% of the soluble fractions of resveratrol loaded in chitosan-coated and chitosan-uncoated emulsions were 14-fold greater than that of resveratrol powder. The findings suggest that the chitosan-coating can enhance both the gut-retention time of resveratrol and its bioavailability, resulting in prolonged bioactivity of non-oxidized resveratrol. Moreover, the colloidal stability of resveratrol-loaded and chitosan-coated emulsions was maintained for 2 months (pH 4; 25 degrees C). This study provides useful information to guide development of an effective oral delivery system for resveratrol.
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