Journal
FOOD CHEMISTRY
Volume 354, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.129529
Keywords
Infant formula; Cholesterol oxidation products; 7-ketochosterol; Infant nutrition; Dietary assessment; Lipidomics
Funding
- SHORA Spectrum Health [RC108332]
- USDA National Institute of Food and Agriculture, Hatch project [MICL02526]
- Michigan State University
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Approximately two-thirds of US infants receive infant formula as a primary or sole nutritional source during the first six months of life. Infant formula is available in a variety of commercial presentations, categorized as powder- or liquid- based formulations.
Approximately two-thirds of US infants receive infant formula (IF) as a primary or sole nutritional source during the first six months of life. IF is available in a variety of commercial presentations; from a manufacturing standpoint, they can be categorized as powder- (PIF) or liquid- (LIF) based formulations. Thirty commercial IFs were analyzed in their oxidative and non-oxidative lipid profiles. We identified 7-ketocholesterol ? a major endproduct of cholesterol oxidation ? as a potential biomarker of IF manufacturing. The statistical analysis allowed a re-classification of IF based on their metabolomic fingerprint, resulting in three groups assigned with low-to-high oxidative status. Finally, we modeled the dietary intake of cholesterol, sterols, and 7-ketocholesterol in the first year of life. The database provided in this study will be instrumental for scientists interested in infant nutrition, to establish bases for epidemiological studies aimed to find connections between nutrition and diet-associated diseases, such as sitosterolemia.
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