Journal
FOOD CHEMISTRY
Volume 353, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.129505
Keywords
Core-shell nano-systems; Carvacrol; In vitro bioaccessibility; Confocal laser scanning microscopy; Sustained delivery
Funding
- Higher Education Commission (HEC), Pakistan [1-8/HEC/HRD/2017/8168, 204260/RD/HEC/14/127]
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Encapsulating carvacrol in chitosan-albumin based core-shell nano-carriers enhances its stability and bioaccessibility under simulated digestion conditions, particularly showing increased stability in the intestinal phase. These core-shell nano-carriers may be an effective means of encapsulating, protecting and delivering hydrophobic bioactive compounds for functional food applications.
The impact of encapsulating carvacrol in chitosan-albumin based core-shell nano-carriers (NCs) on its stability and bioaccessibility was determined under simulated digestion conditions. These NCs consisted of chitosan (C) core enclosed by bovine serum albumin (BSA) shell. The mean particle size ranged from 52.4 +/- 10 nm to 203 +/- 6 nm and zeta-potential from + 21 +/- 3.6 to -18 +/- 2.7 mV. The size and charge were significantly modified after the protein-shell formation around the polysaccharide-core. Core-shell NCs were more stable, with less aggregation under simulated gastrointestinal conditions than C-NCs, presumably due to greater steric repulsion. Likewise, core-shell NCs were observed relatively more stabilized in the intestinal phase than gastric phase. The bioaccessibility of carvacrol was enhanced significantly when it was encapsulated in the core-shell NCs. These findings imply that C-BSA based core-shell NCs might be an efficient means of encapsulating, protecting and delivering hydrophobic bioactive compounds for applications in functional foods.
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