Gut microbiota influence on oral bioaccessibility and intestinal transport of pesticides in Chaenomeles speciosa

There is limited research focusing on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. In the present study, we use a modified setup of the Simulator of the Human Intestinal Microbial Ecosystem for the determination of pesticide residue bioaccessibility in Chaenomeles speciosa, and a Caco-2 cell model of human intestinal absorption. Results showed that gut micro-biota played a dual role based their effects on contaminant release and metabolism in the bioaccessibility assay, and Lactobacillus plantarum was one of key bacterial species in the gut microbiota that influenced pesticide stability significantly. The addition of L. plantarum to the system reduced the relative amounts (by 11.40-86.51%) of six pesticides. The interaction between the food matrix and human gut microbiota led to different absorption rates, and the barrier effects increased with an increase in incubation time.

Automated summary

Limited research has been conducted on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. This study found that gut microbiota play a dual role in contaminant release and metabolism, with Lactobacillus plantarum being a key bacterial species that significantly influences pesticide stability. The addition of L. plantarum to the system can reduce the relative amounts of pesticides, and the interaction between the food matrix and human gut microbiota leads to different absorption rates, with barrier effects increasing over time.