Related references
Note: Only part of the references are listed.Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective
Hugo M. Vargas et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)
Combined lifestyle factors, all-cause mortality and cardiovascular disease: a systematic review and meta-analysis of prospective cohort studies
Yan-Bo Zhang et al.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH (2021)
Cellular model systems to study cardiovascular injury from chemotherapy
Hananeh Fonoudi et al.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)
Enhanced structural maturation of human induced pluripotent stem cell-derived cardiomyocytes under a controlled microenvironment in a microfluidic system
Tomasz Jan Kolanowski et al.
ACTA BIOMATERIALIA (2020)
Detection of Drug-Induced Torsades de Pointes Arrhythmia Mechanisms Using hiPSC-CM Syncytial Monolayers in a High-Throughput Screening Voltage Sensitive Dye Assay
Andre Monteiro da Rocha et al.
TOXICOLOGICAL SCIENCES (2020)
Enhancement of human iPSC-derived cardiomyocyte maturation by chemical conditioning in a 3D environment
Chen Yu Huang et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)
Human In Vitro Models for Assessing the Genomic Basis of Chemotherapy-Induced Cardiovascular Toxicity
Emily A. Pinheiro et al.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2020)
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
Elisa Giacomelli et al.
CELL STEM CELL (2020)
A Brief Review of Current Maturation Methods for Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes
Razan Elfadil Ahmed et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Cardiovascular Effects of Polychlorinated Biphenyls and Their Major Metabolites
Fabian A. Grimm et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2020)
The association between environmental endocrine disruptors and cardiovascular diseases: A systematic review and meta-analysis
Xiangjun Fu et al.
ENVIRONMENTAL RESEARCH (2020)
An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)
Amy M. Avila et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2020)
Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method
Mahnaz Maddah et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2020)
A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model
Alexander D. Blanchette et al.
TOXICOLOGICAL SCIENCES (2020)
Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity
Jessica M. Miller et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)
A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling
Yimu Zhao et al.
CELL (2019)
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway
Richard J. Mills et al.
CELL STEM CELL (2019)
Thorough QT/QTc in a Dish: Can Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Predict Thorough QT Outcomes?
Hugo M. Vargas
CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)
Prolonged post-differentiation culture influences the expression and biophysics of Na+ and Ca2+ channels in induced pluripotent stem cell-derived ventricular-like cardiomyocytes
Gracious R. Ross et al.
CELL AND TISSUE RESEARCH (2019)
Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming
Huan Wang et al.
CELL SYSTEMS (2019)
Myocarditis in the Setting of Cancer Therapeutics Proposed Case Definitions for Emerging Clinical Syndromes in Cardio-Oncology
Marc P. Bonaca et al.
CIRCULATION (2019)
Physiological Biomimetic Culture System for Pig and Human Heart Slices
Qinghui Ou et al.
CIRCULATION RESEARCH (2019)
Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs
Ksenia Blinova et al.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2019)
Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture
Caroline Halloin et al.
STEM CELL REPORTS (2019)
Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations
Mandeep Atwal et al.
MOLECULAR PHARMACOLOGY (2019)
Engineered Cardiac Tissues Generated in the Biowire II: A Platform for Human-Based Drug Discovery
Nicole T. Feric et al.
TOXICOLOGICAL SCIENCES (2019)
Comparative effects of parent and heated cinnamaldehyde on the function of human iPSC-derived cardiac myocytes
Matthew A. Nystoriak et al.
TOXICOLOGY IN VITRO (2019)
Workshop Report FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms
Li Pang et al.
CIRCULATION RESEARCH (2019)
Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes
Sarah D. Burnett et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)
World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions
Emanuele Di Angelantonio et al.
LANCET GLOBAL HEALTH (2019)
Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells
Xiulan Yang et al.
STEM CELL REPORTS (2019)
Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships
Alexander D. Blanchette et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)
Application of human pluripotent stem cells and pluripotent stem cell-derived cellular models for assessing drug toxicity
Agota Apati et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2019)
miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity
Shashi Kumar Gupta et al.
MOLECULAR THERAPY (2019)
3D Cardiac Cell Culture: A Critical Review of Current Technologies and Applications
Christian Zuppinger
FRONTIERS IN CARDIOVASCULAR MEDICINE (2019)
Real-world heart rate norms in the Health eHeart study
Robert Avram et al.
NPJ DIGITAL MEDICINE (2019)
The impact of in vitro cell culture duration on the maturation of human cardiomyocytes derived from induced pluripotent stem cells of myogenic origin
Jaroslaw Lewandowski et al.
CELL TRANSPLANTATION (2018)
CRISPR/Cas9 editing in human pluripotent stemcell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy
Diogo Mosqueira et al.
EUROPEAN HEART JOURNAL (2018)
Advanced maturation of human cardiac tissue grown from pluripotent stem cells
Kacey Ronaldson-Bouchard et al.
NATURE (2018)
Pesticides and cardiotoxicity. Where do we stand?
Nikolaos Georgiadis et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)
A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening
Fabian A. Grimm et al.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2018)
Cardiovascular disease: The rise of the genetic risk score
Joshua W. Knowles et al.
PLOS MEDICINE (2018)
Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system
Carlota Oleaga et al.
BIOMATERIALS (2018)
Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes
Kwong-Man Ng et al.
SCIENTIFIC REPORTS (2018)
International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
Ksenia Blinova et al.
CELL REPORTS (2018)
Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload
Zhen Ma et al.
NATURE BIOMEDICAL ENGINEERING (2018)
Light-Activated Dynamic Clamp Using iPSC-Derived Cardiomyocytes
Bonnie Quach et al.
BIOPHYSICAL JOURNAL (2018)
Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification
Andrew J. Shapiro et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2018)
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017
Gregory A. Roth et al.
LANCET (2018)
Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking
Ivan Kopljar et al.
STEM CELL REPORTS (2018)
Cardiomyocyte-Endothelial Cell Interactions in Cardiac Remodeling and Regeneration
Virpi Talman et al.
FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)
Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
Umesh Chaudhari et al.
ARCHIVES OF TOXICOLOGY (2018)
Evaluation and management of chemotherapy-induced cardiotoxicity in breast cancer: a Delphi study
J. Gavila et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2017)
Diseases due to unhealthy environments: an updated estimate of the global burden of disease attributable to environmental determinants of health
A. Pruss-Ustun et al.
JOURNAL OF PUBLIC HEALTH (2017)
Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
Ksenia Blinova et al.
TOXICOLOGICAL SCIENCES (2017)
Nonhuman Primates and Translational Research-Cardiovascular Disease
Laura A. Cox et al.
ILAR JOURNAL (2017)
Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research
Katharina Kroll et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2017)
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
Arun Sharma et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model
Oksana Sirenko et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)
A Tiered, Bayesian Approach to Estimating Population Variability for Regulatory Decision-Making
Weihsueh A. Chiu et al.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2017)
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
Masahide Kawatou et al.
NATURE COMMUNICATIONS (2017)
A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes
Hiroyuki Ando et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2017)
Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative
Kiyoshi Takasuna et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2017)
Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes
Susann Bjork et al.
FRONTIERS IN PHYSIOLOGY (2017)
iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types
Athanasia D. Panopoulos et al.
STEM CELL REPORTS (2017)
Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes
Tadahiro Shinozawa et al.
STEM CELL REPORTS (2017)
Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes
Hendrik Lapp et al.
SCIENTIFIC REPORTS (2017)
hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen
Andre Monteiro da Rocha et al.
SCIENTIFIC REPORTS (2017)
Cancer Treatment-Induced Arrhythmias Focus on Chemotherapy and Targeted Therapies
Vitaly Buza et al.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2017)
Phenotypic Assays for Characterizing Compound Effects on Induced Pluripotent Stem Cell-Derived Cardiac Spheroids
Oksana Sirenko et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2017)
Cardiotoxicity screening: a review of rapid-throughput in vitro approaches
Xichun Li et al.
ARCHIVES OF TOXICOLOGY (2016)
Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
Umesh Chaudhari et al.
ARCHIVES OF TOXICOLOGY (2016)
High-throughput drug profiling with voltage-and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes
Stephane Bedut et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)
Post-marketing withdrawal of anti-obesity medicinal products because of adverse drug reactions: a systematic review
Igho J. Onakpoya et al.
BMC MEDICINE (2016)
The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels
Veronika Matschke et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
Paul W. Burridge et al.
NATURE MEDICINE (2016)
Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse
Brian R. Berridge et al.
Journal of Toxicologic Pathology (2016)
Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging
Graham T. Dempsey et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)
The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative Update on progress
Thomas Colatsky et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)
Computational investigations of hERG channel blockers: New insights and current predictive models
Bruno O. Villoutreix et al.
ADVANCED DRUG DELIVERY REVIEWS (2015)
High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes
Fabian Alexander Grimm et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2015)
Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy
Haodi Wu et al.
CELL STEM CELL (2015)
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Insights Into Molecular, Cellular, and Functional Phenotypes
Ioannis Karakikes et al.
CIRCULATION RESEARCH (2015)
Historical exposure to persistent organic pollutants and risk of incident hypertension
Juan P. Arrebola et al.
ENVIRONMENTAL RESEARCH (2015)
Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations
Atara Novak et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)
Cardiac differentiation of human pluripotent stem cells in scalable suspension culture
Henning Kempf et al.
NATURE PROTOCOLS (2015)
Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Amy Pointon et al.
TOXICOLOGICAL SCIENCES (2015)
Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells
Lu Han et al.
CARDIOVASCULAR RESEARCH (2014)
Reducing attrition in drug development: smart loading preclinical safety assessment
Ruth A. Roberts et al.
DRUG DISCOVERY TODAY (2014)
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
Gang Wang et al.
NATURE MEDICINE (2014)
Small and large animal models in cardiac contraction research: Advantages and disadvantages
Nima Milani-Nejad et al.
PHARMACOLOGY & THERAPEUTICS (2014)
Progress in computational toxicology
Sean Ekins
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2014)
Endothelin-1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Atsushi Tanaka et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)
Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype
Christine Y. Ivashchenko et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)
Screening Drug-Induced Arrhythmia Events Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays
Enrique G. Navarrete et al.
CIRCULATION (2013)
Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture
Tsukasa Kamakura et al.
CIRCULATION JOURNAL (2013)
Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery
Mark Mercola et al.
CIRCULATION RESEARCH (2013)
Dealing with Global Safety Issues Was the Response to QT-Liability of Non-Cardiac Drugs Well Coordinated?
Norman Stockbridge et al.
DRUG SAFETY (2013)
Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity
Nicola Ferri et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Integrated and translational nonclinical in vivo cardiovascular risk assessment: Gaps and opportunities
Brian R. Berridge et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2013)
Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells
Scott D. Lundy et al.
STEM CELLS AND DEVELOPMENT (2013)
Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem CellDerived Cardiomyocytes to Functional Preclinical Safety Assays
Kate Harris et al.
TOXICOLOGICAL SCIENCES (2013)
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity
Oksana Sirenko et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)
CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia
E. Di Pasquale et al.
CELL DEATH & DISEASE (2013)
A Review of Human Pluripotent Stem Cell-Derived Cardiomyocytes for High-Throughput Drug Discovery, Cardiotoxicity Screening, and Publication Standards
Nicholas M. Mordwinkin et al.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2013)
Multiparameter In Vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using iPSC Cells
Oksana Sirenko et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Phenotypic Screening with Human iPS Cell-Derived Cardiomyocytes: HTS-Compatible Assays for Interrogating Cardiac Hypertrophy
Coby Carlson et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Disease characterization using LQTS-specific induced pluripotent stem cells
Toru Egashira et al.
CARDIOVASCULAR RESEARCH (2012)
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
Anna L. Lahti et al.
DISEASE MODELS & MECHANISMS (2012)
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
Christian B. Jung et al.
EMBO MOLECULAR MEDICINE (2012)
The determination and interpretation of the therapeutic index in drug development
Patrick Y. Muller et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Incidence and Risk of QTc Interval Prolongation among Cancer Patients Treated with Vandetanib: A Systematic Review and Meta-analysis
Jiajie Zang et al.
PLOS ONE (2012)
Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations
Kirsi Kujala et al.
PLOS ONE (2012)
Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
Ning Sun et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Characterization of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Bioenergetics and Utilization in Safety Screening
Payal Rana et al.
TOXICOLOGICAL SCIENCES (2012)
Swine as Models in Biomedical Research and Toxicology Testing
M. M. Swindle et al.
VETERINARY PATHOLOGY (2012)
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents
Junyi Ma et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)
How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
H. G. Laverty et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Opportunities for Use of Human iPS Cells in Predictive Toxicology
B. D. Anson et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification
Hsiang-Po Huang et al.
HUMAN MOLECULAR GENETICS (2011)
Modelling the long QT syndrome with induced pluripotent stem cells
Ilanit Itzhaki et al.
NATURE (2011)
Calcium Handling in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
Ilanit Itzhaki et al.
PLOS ONE (2011)
Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Liang Guo et al.
TOXICOLOGICAL SCIENCES (2011)
Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations
J. D. Cohen et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2011)
Combination of Functional Cardiomyocytes Derived from Human Stem Cells and a Highly-Efficient Microelectrode Array System: An Ideal Hybrid Model Assay for Drug Development
Yasuyuki Asai et al.
CURRENT STEM CELL RESEARCH & THERAPY (2010)
Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products
Jan Willem van der Laan et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2010)
Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells
Limor Zwi et al.
CIRCULATION (2009)
Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
Jianhua Zhang et al.
CIRCULATION RESEARCH (2009)
The use of in vivo zebrafish assays in drug toxicity screening
Peter M. Eimon et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Cardiovascular Complications of Cancer Therapy Incidence, Pathogenesis, Diagnosis, and Management
Edward T. H. Yeh et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
John Dunlop et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Benchmarking Safety Pharmacology regulatory packages and best practice
Silvana Lindgren et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2008)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Kazutoshi Takahashi et al.
CELL (2007)
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
Michael A. Laflamme et al.
NATURE BIOTECHNOLOGY (2007)
Assessment of QT liabilities in drug development
C. Arrigoni et al.
CELL BIOLOGY AND TOXICOLOGY (2007)
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
Kazutoshi Takahashi et al.
CELL (2006)
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
WS Redfern et al.
CARDIOVASCULAR RESEARCH (2003)
Guidelines for application of chemical-specific adjustment factors in dose/concentration - response assessment.
ME Meek et al.
TOXICOLOGY (2002)