Journal
EXPERIMENTAL NEUROLOGY
Volume 337, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2020.113590
Keywords
SAMP8; Rotarod exercise; Neuroinflammation; M1 phenotype microglia; A1 phenotype astrocyte; Nitric oxide synthase activity
Categories
Funding
- JSPS KAKENHI [JP20H04039]
- JSPS [20J14080]
- Grants-in-Aid for Scientific Research [20J14080] Funding Source: KAKEN
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This study found that low-intensity motor balance and coordination exercise prevented age-related cognitive decline in the early stage of Alzheimer's disease progression. This type of exercise may work by suppressing hippocampal A beta deposition, neuronal loss, oxidative stress, and neuroinflammation, including reduced M1 and A1 phenotypes microglia and astrocytes.
It is well known that physical exercise reduces the risk of Alzheimer's disease (AD) and age-related cognitive decline. However, its mechanisms are still not fully understood. This study aimed to investigate the effect of aging and rotarod exercise (Ex) on cognitive function and AD pathogenesis in the hippocampus using senescence-accelerated mice prone 8 (SAMP8). Cognitive functions clearly declined at 9-months of age. Amyloid-beta (A beta) deposition, neuronal loss, and glia activation-induced neuroinflammation increased with aging. The mtarod Ex prevented the decline of cognitive functions corresponding to the suppression of A beta deposition, neuroinflammation, neuronal loss, inducible nitric oxide synthase (NOS) activities, and neuronal NOS activities. In addition, the rotarod Ex suppressed proinflammatory M1 phenotype microglia and A1 phenotype astrocytes. Our findings suggest that low-intensity motor balance and coordination exercise prevented age-related cognitive decline in the early stage of AD progression, possibly through the suppression of hippocampal A beta deposition, neuronal loss, oxidative stress, and neuroinflammation, including reduced M1 and A1 phenotypes microglia and astrocytes.
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