4.7 Article

Chronic intermittent hypoxia alters main olfactory bulb activity and olfaction

Journal

EXPERIMENTAL NEUROLOGY
Volume 340, Issue -, Pages -

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2021.113653

Keywords

Chronic intermittent hypoxia; Obstructive sleep apnea; Main olfactory bulb; Habituation; dishabituation test; Buried food test; Olfactory dysfunction; Network activity

Categories

Funding

  1. Direccion General de Asuntos del Personal Academico, UNAM, Mexico [IN202018, IG200521]
  2. CONACyT, Mexico [A1-S-7540]

Ask authors/readers for more resources

The study found that exposure to CIH altered MOB network activity and response to odors in mice, leading to olfactory impairment. These changes suggest that CIH may be one of the reasons for olfactory problems in patients with OSA.
Olfactory dysfunction is commonly observed in patients with obstructive sleep apnea (OSA), which is related to chronic intermittent hypoxia (CIH). OSA patients exhibit alterations in discrimination, identification and odor detection threshold. These olfactory functions strongly rely on neuronal processing within the main olfactory bulb (MOB). However, a direct evaluation of the effects of controlled CIH on olfaction and MOB network activity has not been performed. Here, we used electrophysiological field recordings in vivo to evaluate the effects of 21day-long CIH on MOB network activity and its response to odors. In addition, we assessed animals ' olfaction with the buried food and habituation/dishabituation tests. We found that mice exposed to CIH show alterations in MOB spontaneous activity in vivo, consisting of a reduction in beta and gamma frequency bands power along with an increase in the theta band power. Likewise, the MOB was less responsive to odor stimulation, since the proportional increase of the power of its population activity in response to four different odorants was smaller than the one observed in control animals. These CIH-induced MOB functional alterations correlate with a reduction in the ability to detect, habituate and discriminate olfactory stimuli. Our findings indicate that CIH generates alterations in the MOB neural network, which could be involved in the olfactory deterioration in patients with OSA.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available