CD9, a tetraspanin target for cancer therapy?

In the present minireview, we intend to provide a brief history of the field of CD9 involvement in oncogenesis and in the metastatic process of cancer, considering its potential value as a tumor-associated antigenic target. Over the years, CD9 has been identified as a favorable prognostic marker or predictor of metastatic potential depending on the cancer type. To understand its implications in cancer beside its use as an antigenic biomarker, it is essential to know its physiological functions, including its molecular partners in a given cell system. Moreover, the discovery that CD9 is one of the most specific and broadly expressed markers of extracellular membrane vesicles, nanometer-sized entities that are released into extracellular space and various physiological body fluids and play a role in intercellular communication under physiological and pathological conditions, notably the establishment of cancer metastases, has added a new dimension to our knowledge of CD9 function in cancer. Here, we will discuss these issues as well as the possible cancer therapeutic implications of CD9, their limitations, and pitfalls.

Automated summary

In this review, the history of CD9 involvement in oncogenesis and cancer metastasis is briefly discussed, highlighting its potential value as a tumor-associated antigenic target. CD9 has been identified as a favorable prognostic marker or predictor of metastatic potential depending on the cancer type. Besides its use as an antigenic biomarker, CD9 plays a role in intercellular communication under physiological and pathological conditions, notably in the establishment of cancer metastases.