Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 895, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2021.173870
Keywords
Allodynia; Enalapril; Overt nociception; Bradykinin; Reserpine
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul-FAPERGS (Brazil) [17/2551-0001082-5]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq [406098/2018-2]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES/PROEX [23038.005450/2020-19, 0578/2020]
- CNPq [307220/2017-6]
- CAPES/PROEX [88882.182]
- CNPq
- CAPES
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Fibromyalgia is a chronic disease characterized by widespread pain, with mechanisms involving kinins and their receptors. ACE inhibitors can enhance pain symptoms by blocking peptide degradation and boosting kinin receptors signaling. In mice, ACE inhibitors enhanced mechanical allodynia induced by reserpine and this effect was prevented by kinin receptor antagonists.
Fibmmyalgia is a potentially disabling chronic disease, characterized by widespread pain and a range of comorbidities such as hypertension. Among the mechanisms involved in fibromyalgia-like pain symptoms are kinins and their B-1 and B-2 receptors. Moreover, angiotensin I converting enzyme (ACE) inhibitors, commonly used as antihypertensive drugs, can enhance pain by blocking the degradation of peptides such as substance P and bradykinin, besides enhancing kinin receptors signalling. We investigated the effect of ACE inhibitors on reserpine-induced fibromyalgia-like pain symptoms and the involvement of kinins in this effect in mice. Nociceptive parameters (mechanical and cold allodynia and overt nociception) were evaluated after ACE inhibitors administration in mice previously treated with reserpine. The role of kinin B-1 and B-2 receptors was investigated using pharmacological antagonism. Additionally, bradykinin levels, as well as the activity of ACE and kininase I, were measured in the sciatic nerve, spinal cord and cerebral cortex of the mice. The ACE inhibitors enalapril and captopril enhanced reserpine-induced mechanical allodynia, and this increase was prevented by kinin B-1 and B-2 receptor antagonists. Substance P and bradykinin caused overt nociception and increased mechanical allodynia in animals treated with reserpine. Reserpine plus ACE inhibitors increased bradykinin-related peptide levels and inhibited ACE activity in pain modulation structures. Since hypertension is a frequent comorbidity affecting fibromyalgia patients, hypertension treatment with ACE inhibitors in these patients should be reviewed once this could enhance fibmmyalgia-like pain symptoms. Thus, the treatment of hypertensive patients with fibromyalgia could include other classes of antihypertensive drugs, different from ACE inhibitors.
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