Oxidative Rearrangement of 2-(2-Aminobenzyl)furans: Synthesis of Functionalized Indoles and Carbazoles

2-(2-Acylvinyl)indoles obtained by oxidative rearrangement of substituted 2-(2-aminobenzyl)furans could be used to construct structural analogues of antifungal alkaloids caulindoles A-D as well as other indole-derived molecules and substituted carbazoles by introducing new reaction centers into the structure of starting materials or by synthetic manipulation with functional groups of the obtained compounds.

Automated summary

2-(2-Acylvinyl)indoles obtained by oxidative rearrangement of substituted 2-(2-aminobenzyl)furans can be used to construct structural analogues of antifungal alkaloids caulindoles A-D and other indole-derived molecules and substituted carbazoles by introducing new reaction centers or manipulating functional groups of the obtained compounds.