Rh(III)-Catalyzed C-H Activation/Annulation of Aryl Hydroxamates with CF3-Containing α-Propargyl α-Amino Acid Derivatives

A series of new orthogonally protected alpha-CF3-substituted alpha-amino carboxylates, and alpha-amino phosphonates decorated with pharmacophore isoquinolone core has been elaborated through the Rh(III)-catalyzed C-H activation/annulation of aryl hydroxamates with propargyl-containing alpha-amino acid derivatives and their phosphorus analogues.

Automated summary

A series of new orthogonally protected alpha-CF3-substituted alpha-amino carboxylates and alpha-amino phosphonates decorated with pharmacophore isoquinolone core have been elaborated through the Rh(III)-catalyzed C-H activation/annulation of aryl hydroxamates with propargyl-containing alpha-amino acid derivatives and their phosphorus analogues.