4.5 Article

One-Pot Synthesis of 5-Amino-1,2,3-triazole Derivatives via Dipolar Azide-Nitrile Cycloaddition and Dimroth Rearrangement under Solvent-Free Conditions

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 9, Pages 1378-1384

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202001620

Keywords

Cyclization; Heterocycles; Synthetic methods; Triazoles

Funding

  1. Russian Science Foundation (grant RSF) [20-73-00291]
  2. Ministry of Science and Higher Education of the Russian Federation
  3. RUDN University Program 5-100
  4. Russian Science Foundation [20-73-00291] Funding Source: Russian Science Foundation

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An efficient one-pot methodology has been developed for the synthesis of 5-amino-1,2,3-triazole derivatives under solvent-free conditions, using a combination of dipolar azide-nitrile cycloaddition and Dimroth rearrangement.
An efficient one-pot methodology for the preparation of 5-amino-1,2,3-triazole derivatives based on the combination of dipolar azide-nitrile cycloaddition with Dimroth rearrangement under solvent-free conditions has been developed.

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