Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 14, Pages 2057-2076Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100071
Keywords
Alkaloid; Heck cyclization; Macrolide; Terpenoid; Total synthesis
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Funding
- Council of Scientific and Industrial Research, New Delhi
- Indian Association for the Cultivation of Science
- SERB, Department of Science and Technology [CRG/2019/001664]
- Council of Scientific and Industrial Research India [02(0294)/17/EMR-II]
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The intramolecular Heck reaction plays a significant role in synthesizing natural products by constructing various cyclic scaffolds. It serves as a strategic step in the synthesis of different natural products.
This review highlights the application of intramolecular Heck reaction in total synthesis of natural products which were successfully synthesized in recent years (2013 to 2019). Heck cyclization was used as one of the strategic steps for constructions of wide variety of cyclic scaffolds essential for preparation of different natural products.
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