DMAP Mediated Efficient Construction of Functionalized Chromenes through One-Pot Reaction of para-Quinone Methides with Allenoates

A novel DMAP-mediated Rauhut-Currier/oxa-Michael addition cascade reaction of hydroxylphenyl-substituted para-quinone methide with allenoate was reported for the first time. A series of functionalized chromenes were successfully obtained with moderate to good yields under this one-pot cascade reaction. The chromene products could be easily transformed into different derivatives and a plausible mechanism was proposed to elucidate this novel reaction.

Automated summary

A novel DMAP-mediated Rauhut-Currier/oxa-Michael addition cascade reaction was reported for the first time, resulting in a series of functionalized chromenes from the reaction of hydroxylphenyl-substituted para-quinone methide with allenoate. The chromene products obtained in moderate to good yields under this one-pot cascade reaction could be easily transformed into different derivatives, and a plausible mechanism was proposed to elucidate this novel reaction.